DIVISION OF HEMATOLOGY-ONCOLOGY

Providers

Physicians | Research Faculty | Psychologists | Nurse Practitioners

Physicians

Dr. Gail Tomlinson Gail Tomlinson, MD, PhD
Professor of Pediatrics, Division Chief of Hematology-Oncology
Greehey Distinguished Chair in the Genetics of Cancer
Division of Hematology-Oncology
210-567-7477 (Division office)
210-562-9116 (GCCRI office)

Education:
M.D., George Washington University Medical School, 1984
Ph.D., biochemistry, Duke University, 1982
B.S., biology, Dickinson College, Carlisle, Penn., 1974

Training:
Fellowship, pediatric hematology-oncology, UT Southwestern Medical Center, Dallas, 1989-92
Fellowship, Department of Pediatrics, M.D. Anderson Cancer Center, Houston, 1988-89
Residency, pediatrics, Children's Hospital National Medical Center, Washington DC, 1984-87

Board Certification:
Pediatrics, 1988
Hematology-Oncology, 1992

Recent Publications:
Mette LA, PulidoSaldivar AM, Poullard NE, Torres IC, Seth SG, Pollock BH, Tomlinson GE.   Reaching High-Risk Underserved Individuals for Cancer Genetic Counseling by Videoteleconferencing.  J Comm Supp Onc,14(4):162-8.

Bansal H, Yihua Q, Iyer SP, Ganapathy S, Proia D, Penalva LO, Urem PJ, Suresh U, Carew JS, Karnad AB, Weitman S, Tomlinson GE, Rao MK, Kornblau SM, Bansal S. 2014. WTAP is a novel oncologenic protein in acute myeloid leukemia. Leukemia 28(5): 1171-4.

Zhao Z, Ma X, Hsiao TH, Lin G, Kosti A, Yu X, Suresh U, Chen Y, Tomlinson G, Pertsemlidis A, Du L. 2014 "A high content morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiation. Oncotarget, 5(9):2499-512.

Lopez-Terrada D, Alaggio R, DeDavila MT, Czauderna P, Hiyama E, Katzensteim H, Leuschner I, Malogolowkin M, Meyers R, Ranganathan S, Tanaka YY, Tomlinson G, Fabre M, Zimmermann A, Finegold MJ. 2014 Towards an International Pediatric Liver Tumor Consensus Classification: Proceedings of the Los Angeles Children’s Oncology Group International Liver Tumors Symposium, Modern Pathology 27(3):472-9.

Rodriguez-Galindo C, Krailo M, Frazier L, Chintagumpala M, Amatruda J, Katzenstein H, Malogolowkin M, Spector L, Pashankar F, Meyers R, Tomlinson GE. Childrens Oncology Group 2013 blueprint for research: Rare tumors Pediatric Blood and Cancer 2013 Jun;60(6):1061-1021.

Sugalski AJ, Davis M, Prasannan L, Saldivar VA, Hung JY, Tomlinson GE. Mesothelioma in a Seven-Year Old Child: Clinical, Histologic and Genetic Features Pediatric Blood and Cancer 2013 Jan;60(1):146-148.

Tomlinson GE, Kappler R. Genetics and Epigenetics of Hepatoblastoma Pediatric Blood and Cancer 2012 Nov;59(5):785-792

Beuten J, Gelfond JAL, Piwkham D, Pollock BH, Winick NJ, Collier A, Tomlinson GE. Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1), Carcinogenesis, 32:1348-1353.

Ziogas A, Horick N, Kinney A, Lowery J, Isaacs C, Griffin C, Moorman P, Edwards K, Hill D, Berg J, Tomlinson GE, Anton-Culver H, Strong L, Dianne Finkelstein D, Plon S. 2011. Clinically relevant changes in family history of cancer over time. JAMA, 306(2) 172-8.

Piwkham D, Gelfond JAL, Rerkamnuaychoke B, Pakakasama S, Rebel VI, Collier AC, Pollock BH, Winick NJ, Tomlinson GE, Beuten J. (2011) Multi-locus association of genetic variants in MLL, CREBBP, EP300 and TOP2A with childhood acute lymphoblastic leukemia in Hispanics from Texas. Cancer Epidemiology, Biomarkers and Prevention, Jun;20(6): 1204-1212.

Plon SE, Wheeler D, Strong L, Tomlinson GE, Pirics M, Meng Q, Cheung H, Begin P, Biegel J, Muzny D, Lewis L, Gibbs R. (2011) Identification of genetic susceptibility to childhood cancer through analysis of genes in parallel, Cancer Genetics Genetics 204: 19-25.

Domchek SM, Friebel TM, Singer CF, Evans DG, Lynch HT, Isaacs C, Garber JE, Neuhausen SL, Matloff E, Eeles R, Pichert G, van t’Veer L, Tung N, Weitzel JN, Couch FJ, Rubinstein WS, Ganz PA, Daly MB, Olopade OI, Tomlinson G, Schildkraut J, Blum JL, Rebbeck TR (2010) Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers with Cancer Risk and Mortality, JAMA, 304:947-975

Bansal H, Bansal S, Rao M, Foley KP, Sang J, Proia DA, Blackman RK, Ying W, Barsoum B, Baer MR, Kelley K, Swords R, Tomlinson GE, Battiwalla M, Giles FJ, Lee KP and Padmanabhan S. 2010. Heat shock protein 90 regulates the expression of Wilms’ tumor 1 protein in myeloid leukemias, Blood 116: 4591-4599

Research interests:
Genetic predisposition to cancer, Hepatoblastoma, Hereditary breast cancer, Other Pediatric Rare Tumors, Population-specific aspects of childhood cancer, von Hippel-Lindau disease

 

Photo of Dr. Anne-Marie LangevinAnne-Marie R. Langevin, MD
Professor of Pediatrics
Principal Investigator, South Texas Pediatric NCI Community Oncology Research Program (NCORP)
Greehey Distinguished Chair in Pediatric Oncology
Division of Hematology-Oncology
210-567-7477

Education:
M.D., University of Montreal; Montreal, Canada, 1980

Postgraduate Training:
Fellowship, Drug Development, University of North Carolina, 1988-89
Fellowship, Pediatrics-Hematology/Oncology, Hospital for Sick Children; Toronto, Canada, 1985-88
Resident, Hematology Med./Path., Hospital Maisonneuve Rosemont; Montreal, Canada, 1983-84
Resident, Hematology, Hospital Ste-Justine; Montreal, Canada, 1983
Resident, Hematology, Hotel-Dieu de Montreal; Montreal, Canada, 1982-83
1980-82 - Jr. Resident, Internal Medicine, Hospital Maisonneuve Rosemont; Montreal, Canada

Board Certification:
Pediatrics, 1997
Hematology/Oncology, 1998

Publications:
Sugalski AJ, Jiwani A, Ketchum NS, Cornell J, Williams R, Heim-Hall J, Hung JY, Langevin AM. 2014. Characterization of Localized Osteosarcoma of the Extremity in Children and Young Adults from a Single Institution in South Texas. J Pediatr Hematol Oncol 36(6):e353-8.

Niece JA, Rogers ZR, Ahmad N, Langevin AM, McClain KL.. Hemophagocytic lymphohistiocytosis in Texas: observations on ethnicity and race. Pediatr Blood Cancer 2010 Mar;54:424-428

Langevin AM, Bernstein M, Kuhn JG, Blaney SM. Ivy P, Sun J, Chen Z, Adamson PC; Children's Oncology Group. A phase II trial of rebeccamycin analogue (NSC#655649) in children with solid tumors:  a Children's Oncology Group study. Pediatr. Blood Cancer 2008 Mar; 50(3):577-80.

Baillargeon J, Lewis M, Estrada J, Grady JJ, Mullins J, Pitney A, Pollock BH, Langevin AM. Demographic correlates of body size changes in children undergoing treatment for acute lymphoblastic leukemia. Pediatr Blood Cancer 2007. Nov;49(6):793-6.

Baillargeon J, Lewis M, Estrada J, Mullins J, Pitney A, Ma JZ, Chisholm GB, Pollock BH, Langevin AM. Obesity and survival in a cohort of predominantly Hispanic children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2006 Sep;28(9):575-578.

Interests: Drug Development in Pediatric Oncology, Development of Cancer Control Studies in Pediatric Oncology, bone and soft tissue sarcomas, solid tumors in children, adolescents and young adults.

 

Photo of Steven Weitman, MD, PhDSteven Weitman, MD, PhD
Professor of Pediatrics and Director of the Institute for Drug Development
Joint Appointment in Pharmacology and Medicine
210-372-1204

Education:
M.D., Medicine, Medical College of Wisconsin, Milwaukee, WI, 1987
Ph.D., Pharmacology, Medical College of Wisconsin, Milwaukee, WI, 1985
M.S., Pharmacology, Medical College of Wisconsin, Milwaukee, WI, 1984
B.S., Microbiology, University of Wisconsin-LaCrosse, LaCrosse, WI, 1978

Postgraduate Training:
1990-1992 - Fellowship, Pediatric Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX
1988-1990 - Residency, Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX
1987-1988 - Internship, Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX

Board Certification:
Pediatrics, 1992
Pediatric Hematology-Oncology, 1998

Recent Publications:
Bonate PL, Cunningham CC, Gaynon P, Jeha S, Kadota R, Lam GN, Razzouk B, Rytting M, Steinherz P, Weitman S, Weitman SD. Population pharmacokinetics of clofarabine and its metabolite 6-ketoclofarabine in adult and pediatric patients with cancer. Cancer Chemother Pharmacol 2011 Apr;67(4):875-890.

Mould DR, Baumann A, Kuhlmann J, Keating MJ, Weitman SD, Hillmen P, Brettman LR, Reif S, Bonate PL. Population pharmacokineticspharmacodynamics or aletuzumab (Campath) in patients with chronic lymphocytic leukaemia and its link to treatment response Br J Clin Pharmacol 2007;64(3):278-291.

Bonate PL, Arthaud L, Cantrell WR, Stephenson K, Secrist JA, Weitman SD. Discovery and development of clofarabine: a nucleoside analogue for treating cancer Nat Rev Drug Discov 2006;5(10):855-863.

Mita AC, Hammond LA, Bonate PL, Weiss G, McCreery H, Syed S, Garrison M, Chu QS, DeBono JS, Jones CB, Weitman SD, Rowinsky EK. Phase I and pharmacokinetic study of tasidotin hydrochloride (ILX651), a third-generation dolastatin-15 analogue, administered weekly for 3 weeks every 28 days in patients with advanced solid tumors Clin Cancer Res 2006;12(17):5207-5215.

Jeha S, Gaynon PS, Razzouk BI, Franklin J, Kadota R, Shen V, Luchtman-Jones L, Rytting M, Bomgaars LR, Rheingold S, Ritchey K, Albano E, Arceci RJ, Goldman S, Griffin T, Altman A, Gordon B, Steinherz L, Weitman SD, Steinherz P. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia J Clin Oncol 2006;24(12):1917-1923.

 

Photo of Ka Wah Chan, MDKa Wah Chan, MD
Clinical Professor of Pediatrics
Methodist Hospital/Texas Transplant Institute

Education:
M.B.B.S., University of Hong Kong, Hong Kong, China, 19747

Postgraduate Training:
1978-1980 - Fellowship, Hematology/Oncology, Memorial Sloan-Kettering Cancer Center at Cornell University, New York, NY
1976-1978 - Fellowship, Hematology/Oncology, University of British Columbia, Vancouver BC Canada
1975-1976 - Residency, Pediatrics, University of British Columbia, Vancouver BC Canada

Board Certification:
Pediatrics, 1992
Pediatrics Hematology/Oncology, 1996

Recent Publications:
Pai SY, Logan B, Griffith LM, Buckley RH, Parrott RE, Dvorak CC, Kapoor N, Hanson IC, Filipovich AH, Jyonouchi S, Sullivan K, Small TN, Burroughs L, Skoda-Smith S, Haight A, Grizzle A, Pulsipher MA, Chan KW, Fuleihan RL, Haddad E, Loechelt B, Aquino VM, Gillio A, Davis J, Knutsen A, SmithAR, Moore TB, Schroeder ML, Goldman FD, Connelly JA, Porteus MH, Xiang Q, Shearer WT, Fleisher TA, Kohn DB, Puck JM, Notarangelo LD, Cowan MJ, O’Reilly RJ. Transplantation of 240 patients with severe combined immunodeficiency (SCID) from 2000-2009: A Primary Immune Deficiency Treatment Consortium Report. N Engl J Med 371: 434-446, 2014

Ponce DM, Eapen M, Sparapani R, O'Brien TA, Chan KW, Chen J, Craddock J, Schultz KR, Wagner JE, Perales MA, Barker JN. In vivo T-cell depletion with myeloablative regimens on outcomes after cord blood transplantation for acute lymphoblastic leukemia in children. Biol Blood Marrow Transplant 21:2173-9, 2015

Burke MJ, Verneris MR, Le Rademacher J, He W, Abdel-Azim H, Abraham AA, Auletta JJ, Ayas M, Brown VI, Cairo MS, Chan KW, Diaz Perez MA, Dvorak CC, Egeler RM, Guilcher GM, Hayashi RJ, Kasow KA, Leung WH, Olsson RF, Pulsipher MA, Shah NN, Thiel E, Kitko CL. Transplant Outcomes for Children with T-Cell Acute Lymphoblastic Leukemia in Second Remission: A Report of the CIBMTR®. Biol Blood Marrow Transplant 21: 2154-9, 2015

 

Chatchawin Assanasen, MD .Chatchawin Assanasen, MD
Associate Professor of Pediatrics
Children’s Cancer Research
Institute Distinguished Chair in Pediatric Oncology

Division of Hematology-Oncology
210-567-7456

Education:
MD, Medicine, St. George's University, School of Medicine, Bay Shore, NY, 1996
BA, Natural Science , University of Pennsylvania, Philadelphia, PA, 1990

Training:
Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX, 2000-03

Residency:
Pediatric , University of Florida College of Medicine Health Science Center, Jacksonville, FL, 1996-1999

Certification:
Pediatrics, 1999; Hematology-Oncology, 2009

Recent Publications:

Ranch D, Crowther B, Arar M, Assanasen C. 2014 Prophylactic eculizumab for kidney transplantation in a child with atypical hemolytic uremic syndrome due to complement factor H mutation. Pediatric Transplant Sep;18(6):E185-9.

Amin R, Bohnert A, Holmes L, Rajasekaran A, Assanasen C. Response to "Childhood clustering in Florida: weighing the evidence". Pediatric Blood Cancer 2010 Jul;54(7):1053-1053.

Amin R, Bohnert A, Holmes L, Rajasekaran A, Assanasen C. Epidemiologic mapping of Florida childhood cancer clusters (Cover Page) Pediatric Blood Cancer 2010 Apr;54(4):511-518.

Kreiger PA, Judkins AR, Russo PA, Biegel JA, Lestini BJ, Assanasen C, Pawel BR. Loss of INI1 expression defines a unique subset of pediatric undifferentiated soft tissue sarcomas. Mod Pathol 2009 Jan;22(1):142-150.

Fine RL, Shah SS, Moulton TA, Yu IR, Fogelman DR, Richardson M, Burris HA, Samuels BL, Assanasen C, Gorroochurn P, Hibshoosh H, Orjuela M, Garvin J, Goldman FD, Dubovsky D, Walterhouse D, Halligan G. Androgen and c-Kit receptors in desmoplastic small round cell tumors resistant to chemotherapy: novel targets for therapy. Cancer Chemother Pharmacol 2007 Mar;59(4):429-437.

Assanasen C, Mineo C, Seetharam D, Yuhanna IS, Marcel YL, Connelly MA, Williams DL, de la Llera-Moya M, Shaul PW, Silver DL. Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling. J Clin Invest 2005 Apr;115(4):969-977.

 

Photo of Sharqat ShahShafqat Shah, MD
Clinical Associate Professor of Pediatrics
Division of Hematology-Oncology
210-567-7480

Education:
M.D., Duke University School of Medicine, Durham, NC, 1991
B.A., Molecular Biology, Johns Hopkins University, 1987

Postgraduate Training:
1994-97
Fellowship, Pediatric Hem/Onc, University of Texas Health Science Center, San Antonio
1991-94
Residency, Pediatrics, Emory University, Atlanta

Board Certification:
Pediatrics, 1994; Hematology/Oncology, 1998

Publications:
Thomas M, Enciso V, Stratton R, Shah S, Winder T, Tayeh M, Roeder E. Metastatic medulloblastoma in an adolescent with Simpson-Golabi Behmel syndrome. Am J Med Genet A. 2012 Oct;158A(10):2534-6.

Abla O, Weitzman S, Blay JY, O‘Neill B, Abrey L, Neuwelt E, Doolittle N, Baehring J, Pradhan K, Martin SE, Guerrera M, Shah S, Ghesquieres H, Silver M, Betensky R, Batchelor T. Primary CNS Lymphoma in Children and Adolescents: A Descriptive Analysis from the International Primary CNS Lymphoma Collaborative Group (IPCG) Clin Cancer Res 2011 Jan;17(2):346-352

Shah S, Baillargeon JG, Pollock BH, Whitenton K. Assessment of Body Image in Childhood Cancer Surivors in South Texas 2006 May. (Abstract #609, American Society of Pediatric Hemtaology/Oncology 2006 Abstracts)

Shah S, Vega R, Hereditary Spherocytosis, Pediatrics in Review, March 2004 K Krishnan, S Shah, H Sabio, V McKie. Mycoplasma Encephalitis Complicates the Course of Acute Chest Syndrome in an Eight-Year old with Sickle Cell Anemia 2001 Mar. p. A32. (Journal of Pediatric Hematology/Oncology; vol. 23, no. 3).

Interests:
Childhood Cancer Survivorship, Neuro-Oncology

 

Dr. Melissa Frei-JonesMelissa Frei-Jones, MD, MSCI

Associate Professor of Pediatrics
Fellowship Program Director 
Interim Director South Texas Hemophilia Treatment Center
Director South Texas Sickle Cell and Thalassemia Center
Division of Hematology-Oncology
210-567-7480

Education:
MSCI, clinical investigation, Washington University, St. Louis, 2008
M.D., Pediatrics, University of Texas Southwestern Medical School,
Dallas, TX, (Summa Cum Laude), 2002
B.S., Latin American Studies, Southern Methodist University,
Dallas, TX, (Summa Cum Laude), 1998
B.A., Biology, Southern Methodist University, Dallas, TX, 1998

Training:
2005-08
Fellowship, Pediatric Hematology-Oncology, Washington University School of Medicine, St. Louis, MO

Residency:
Pediatrics , University of Texas Southwestern Medical School, Dallas, TX, 2002-2005

Certification:
Pediatrics, 2005; Hematology-Oncology, 2009 American Board of Pediatrics

Publications:
Kane LC, Woodward CS, Husain SA, Frei-Jones MJ. Thromboelastography--does it impact blood component transfusion in pediatric heart surgery? J Surg Res. 2016 Jan;200(1):21-7.

Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen SC, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, Wen J, Valentine M, Cheng C, Paugh SW, Devidas M, Chen IM, Reshmi S, Smith A, Hedlund E, Gupta P, Nagahawatte P, Wu G, Chen X, Yergeau D, Vadodaria B, Mulder H, Winick NJ, Larsen EC, Carroll WL, Heerema NA, Carroll AJ, Grayson G, Tasian SK, Moore AS, Keller F, Frei-Jones M, Whitlock JA, Raetz EA, White DL, Hughes TP, Guidry Auvil JM, Smith MA, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui CH, Jeha S, Relling MV, Evans WE, Gerhard DS, Gastier-Foster JM, Mardis E, Wilson RK, Loh ML, Downing JR, Hunger SP, Willman CL, Zhang J, Mullighan CG. 2014. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med. 2014 Sep 11;371(11):1005-15.

Jessen B, Bode SF, Ammann S, Chakravorty S, Davies G, Diestelhorst J, Frei-Jones M, Gahl WA, Gochuico BR, Griese M, Griffiths G, Janka G, Klein C, Kögl T, Kurnik K, Lehmberg K, Maul-Pavicic A, Mumford AD, Pace D, Parvaneh N, Rezaei N, de Saint Basile G, Schmitt-Graeff A, Schwarz K, Karasu GT, Zieger B, Zur Stadt U, Aichele P, Ehl S. The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2. Blood. 2013 Apr 11;121(15):2943-51.

Gochuico BR, Huizing M, Golas GA, Scher CD, Tsokos M, Denver SD, Frei-Jones MJ, Gahl WA. Interstitial lung disease and pulmonary fibrosis in Hermansky-Pudlak syndrome type 2, an adaptor protein-3 complex disease. Mol Med. 2012 Feb 10;18:56-64.

Regan MM, Debaun MR, Frei-Jones MJ. Multi-modal intervention for the inpatient management of sickle cell pain significantly decreases the rate of acute chest syndrome. Pediatric Blood Cancer 2011 Feb; 56(2):262-6.

Chiang PW, Spector E, Thomas M, Frei-Jones M. Novel mutation causing Hemansky-Pudlak Syndrome, Type 2. Pediatric Blood Cancer 2010 Dec 15(55(7): 1438.

Frei-Jones MJ, Field JJ, DeBaun MR. Multi-modal intervention and prospective implementation of standardized sickle cell pain admission orders reduces 30-day readmission rate. Pediatric Blood Cancer 2009 Sept; 53(3):401-5.

Frei-Jones MJ, Field JJ, DeBaun MR.  Risk factors for hospital readmission within 30 days:  a new quality measure for children with sickle cell disease.   Pediatr. Blood Cancer 2009 Apr; 52(4):481-5.

Frei-Jones M, McKinstry R, Perry A, Leonard JR, Park TS, Rubin JB.  Use of thalidomide to diminish growth velocity in a life-threatening congenital hemangoma.  J. Neurosurg. Pediatr. 2008 Aug;2(2);125-9.

Frei-Jones MJ, Baxter AL, Rogers ZR, Buchanan GR.  Vaso-occlusive episodes in older children with sickle cell disease:  emergency department management and pain assessment.  J. Pediatr. 2008 Feb;152(2):281-5.

Interests:
Sickle cell disease, benign hematology, vascular tumors

 

Gregory Aune MD, PhDGregory Aune MD, PhD
Assistant Professor of Pediatrics
Division of Hematology-Oncology
210-562-9154

Education:
B.S., 1997 Pacific Lutheran University (Summa Cum Laude)
MD, Medicine, University of Texas at Houston, Houston, TX, 2005
PhD, Biomedical Sciences, University of Texas at Houston, Houston, TX, 2005

Training:
2008-2010 - Fellowship, Hematology/Oncology, University of Texas Health Science Center San Antonio
2005-2008 - Residency, Pediatrics, Johns Hopkins Hospital, Baltimore, MD

Residency:
Pediatric, Johns Hopkins Hospital, Baltimore, MD, 2005-2008

Board Certification:
Pediatrics, 2009
Pediatric Hematology-Oncology, 2011

Recent Publications:
Lindsey ML, Lange RA, Parsons H, Andrews T, Aune GJ. The tell-tale heart: molecular and cellular responses to childhood anthracycline exposure. Am J Physiol Heart Circ Physiol. 2014 Nov 15;307(10):H1379-H1389. doi: 10.1152/ajpheart.00099.2014. Epub 2014 Sep 12. Review. PMID: 25217655 [PubMed - as supplied by publisher]

Pan H, Qin K, Guo Z, Ma Y, April C, Gao X, Andrews TG, Bokov A, Zhang J, Chen Y, Weintraub ST, Fan JB, Wang D, Hu Y, Aune GJ, Lindsey ML, Li R. Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell Rep. 2014 Apr 10;7(1):79-85. doi: 10.1016/j.celrep.2014.02.028. Epub 2014 Mar 20. PMID: 24656816 [PubMed - in process] Free Article

Andrews TG, Lindsey ML, Lange RA, Aune GJ. Cardiac assessment in pediatric mice: strain analysis as a diagnostic measurement. Echocardiography. 2014 Mar;31(3):375-84. doi: 10.1111/echo.12351. Epub 2013 Sep 19. PMID: 24103064 [PubMed - in process]

Patterson NL, Iyer RP, de Castro Brás LE, Li Y, Andrews TG, Aune GJ, Lange RA, Lindsey ML. Using proteomics to uncover extracellular matrix interactions during cardiac remodeling. Proteomics Clin Appl. 2013 Aug;7(7-8):516-27. doi: 10.1002/prca.201200100. Epub 2013 Jul 8. Review. PMID: 23532927 [PubMed - indexed for MEDLINE] Free PMC Article

Policarpio-Nicolas ML, Valente PT, Aune GJ, Higgins RA. Isolated vaginal myeloid sarcoma in a 16-year-old girl. Ann Diagn Pathol. 2012 Oct;16(5):374-9. doi: 10.1016/j.anndiagpath.2011.01.009. Epub 2011 Jun 11. PMID: 21658983 [PubMed - indexed for MEDLINE]

Pan H, Qin K, Guo Z, Ma Y, April C, Gao X, Andrews TG, Bokov A, Zhang J, Chen Y, Weintraub ST, Fan JB, Wang D, Hu Y, Aune GJ, Lindsey ML, Li R. 2014. Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell Rep. 10;7(1):79-85.

Andrews TG, Lindsey ML, Lange RA, Aune GJ. 2014. Cardiac Assessment in Pediatric Mice Echocardiography. Echocardiography 31(3):375-84.

Patterson NL, Iyer RP, de Castro Brás LE, Li Y, Andrews TG, Aune GJ, Lange RA, Lindsey ML. 2013 Using proteomics to uncover extracellular matrix interactions during cardiac remodeling. Proteomics Clin Appl. 2013 Aug;7(7-8):516-27

Policarpio-Nicolas ML, Valente PT, Aune GJ, Higgins RA. Isolated vaginal myeloid sarcoma in a 16-year-old girl. Ann Diagn Pathol. 2011.

Aune GJ, Takagi K, Sordet O, Guirouilh-Barbat J, Antony S, Bohr VA, Pommier Y. 2008. Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectidin. Clin. Cancer Research 14(20):6449-55.

Aune GJ. 2008. Wilms Tumor. Pediatr. Rev. 29(4):142-3.

Aune GJ, Furuta T, and Pommier Y. Ecteinascidin 743: A novel anticancer drug with a unique mechanism of action. Anti-Cancer Drugs 13: 1-12. 2002

Interests:
Cardiovascular disease in long-term childhood cancer survivors, Survivorship, Mouse models of chemotherapy and radiation induced cardiotoxicity, miRNAs, Ventricular remodeling

http://ccri.uthscsa.edu/gaune.asp

 

Allison Grimes, MDAllison Grimes, MD
Assistant Professor of Pediatrics
Division of Hematology-Oncology
210-567-7477

Education:
M.D., UT Health Science Center San Antonio School of Medicine, 2009
B.A., Philosophy, Honors Program, Magna Cum Laude, Interdisciplinary Core/Minors: Chemistry, Biology, 2004

Training:
Fellowship, Pediatric Hematology-Oncology, UT Health Science Center San Antonio, 2012-2015
Residency, Pediatrics, UT Health Science Center San Antonio, 2009-2012

Residency:
Pediatrics, 2012

Board Certification:
Pediatrics, 2012
Pediatric Hematology-Oncology, board eligible 2017

Recent Publications:
Meyer D, Becker E, Grimes A, Villareal D, Libow L, Davis T, Assanasen C, Browning J. Systemic Juvenile Xanthogranuloma: A Case Report and Brief Review. Journal of Pediatric Dermatology, 2013.

Grimes, Allison C. (2012) “All That Wheezes…” Hospitalist Pediatrics, vol 2, issue 1, January 2012, 47-50.

Grimes, Allison C. (2009) “A Survey of Limb Development through Carnegie Stages 12-23.” Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio School of Medicine, 2009.

Grimes, Allison C. (2008) “The Lesson.” Alumni Connection newsletter, vol IV, issue 2, University of Texas Health Science Center at San Antonio Alumni Association, 2008.

Backus, Allison C. (2005). “Anatomy of the Ear.” University of Texas Health Science Center at San Antonio, Department of Cellular & Molecular Biology, 2005.

Backus, Allison C. (2004). “Child Phenomenology in Pediatric Terminal Care.” Baylor Univ Press, 2004.

Interests:
Genetic Markers for Chemotherapy-Related Pancreatitis in Childhood ALL and Tumor-Derived Prolactin in T-ALL

 

Aaron Sugalski, DOAaron Sugalski, DO
Assistant Professor of Pediatrics
Division of Hematology-Oncology
210-567-7483

Education:
D.O., Osteopathy, Kirksville College of Osteopathic Medicine,
Kirksville, MO, 2006
B.S., Biomedical Sciences, Minor in Business,
Texas A&M University, College Station, TX, 2004

Postgraduate Training:
2009-2012 - Fellowship, Hematology/Oncology, University of Texas Health Science Center, San Antonio, TX
2006-2009 - Residency, Pediatrics, University of Texas Health Science Center, San Antonio, TX

Board Certification:
Pediatrics, 2009
Pediatric Hematology/Oncology, 2012

Publications:
Sugalski AJ, Jiwani A, Ketchum NS, Cornell J, Williams R, Heim-Hall J, Hung JY, Langevin AM. Characterization of localized osteosarcoma of the extremity in children, adolescents, and young adults from a single institution in South Texas. J Pediatr Hematol Oncol. 2014 Aug;36(6):e353-8. doi: 10.1097/MPH.0000000000000104. PMID: 24487915 [PubMed - indexed for MEDLINE] Free PMC Article

Sugalski A, Davis M, Prasannan L, Saldivar V, Hung JY, Tomlinson GE. Clinical, histologic, and genetic features of mesothelioma in a 7-year-old child. Pediatr Blood Cancer. 2013 Jan;60(1):146-8. doi: 10.1002/pbc.24284. Epub 2012 Sep 7. PMID: 22961710 [PubMed - indexed for MEDLINE]

Sanchez-Diaz PC, Hsiao TH, Zou Y, Sugalski AJ, Heim-Hall J, Chen Y, Langevin AM, Hung JY.  In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma.  Oncoscience.  2014 Sep 23; 1(9):599-608. eCollection 2014.  PMID: 25594070

Interests:
Characterization of osteosarcoma in children, adolescents, and young adults from South Texas

Investigation into the expression of the ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) enzyme in cancer stem cells of osteosarcoma and neuroblastoma and its relationship to patient prognosis and outcome.

Quality Improvement Processes applicable to Pediatric Hem/Onc Care

Education of medical students and residents.

Cancer Care Delivery Research

 

Research Faculty

Alexander Pertsemlidis, PhDAlexander Pertsemlidis, PhD
Associate Professor (tenured) of Pediatrics and Cellular and Structural Biology
Division of Hematology-Oncology
Greehey Children’s Cancer Research Institute
210-562-9062

Education:
Ph.D., Biophysics, University of California, Berkeley, CA, 1995
M.S., Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, 1988
B.A., Medieval History, Princeton University, Princeton, NJ, 1987

Post-Doctoral Training:
1999-2000 - Computational Biology and Genetics, University of Texas Southwestern Medical Center, Dallas, TX
1996-1999 - Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX

Recent Publications:
Zhao Z, Ma X, Sung D, Li M, Kosti A, Lin G, Chen Y, Pertsemlidis A, Hsiao TH, Du L. microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest. RNA Biology 2015;12(5):538-54.

Borkowski R, Du L, Zhao Z, McMillan E, Kosti AK, Yang CR, Suraokar M, Wistuba II, Gazdar AF, Minna JD, White MA, Pertsemlidis A. Genetic mutation of p53 and suppression of the miR-17~92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D signaling. Cancer Research, Cancer Research 2015;75(4):666-75. PMID: 25519225.

Masi M, Frolova LV, Yu X, Mathieu V, Cimmino A, De Carvalho A, Kiss R, Rogelj S, Pertsemlidis A, Kornienko A, Evidente A. Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer. Fitoterapia 2015;102:41-8.

Zhao Z, Ma X, Hsiao TH, Lin G, Kosti A, Yu X, Suresh U, Chen Y, Tomlinson G, Pertsemlidis A, Du L. 2014. A high-content morphological screen identified novel microRNAs that regulate neuroblastoma cell differentiation. Oncotarget 2014;5(9):2499-512.

Du L, Zhao Z, Ma X, Hsiao TH, Chen Y, Young E, Suraokar M, Wistuba I, Minna JD, Pertsemlidis A. miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer. Oncogene 2014;33:4307-4315.

Du L, Borkowski R, Zhao Z, Ma X, Yu X, Xie XJ, Pertsemlidis A. A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. RNA Biol 2013;10:1700-1713.

Ahn YH, Gibbons DL, Chakravarti D, Creighton CJ, Rizvi ZH, Adams HP, Pertsemlidis A, Gregory PA, Wright JA, Goodall GJ, Flores ER, Kurie JM. ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. J Clin Invest 2012;122:3170-3183.

Du L and Pertsemlidis A. microRNA regulation of cell viability and drug sensitivity in lung cancer. Expert Opinion on Biological Therapy 2012;12(9):1221-39.

Du L, Subauste MC, DeSevo C, Zhao Z, Baker M, Borkowski R, Schageman JJ, Greer R, Yang CR, Suraokar M, Wistuba, II, Gazdar AF, Minna JD, Pertsemlidis A. miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers. PLoS One 2012;7:e39167.

Interests:
Noncoding RNA Biology, drug response in cancer cells, neuroblastoma, lung cancer, computational biology

 

Christina AguilarChristine Aguilar, MD, MPH
Faculty Associate
Division of Hematology-Oncology
210-562-9123

Education:
M.S., Biology, Universidad de Monterrey, Mexico, 1974
M.D., Medicine, Universidad Autonoma de Nuevo Leon, 1980
M.P.H., UT Health Science Center, San Antonio, 1989

Recent Publications:
Zebrack B, Block R, Hayes-Lattin B, Embry L, Aguilar C, Meeske K, Yun L, Butler M.  Psychosocial service Use and Unmet Need Among Recently-Diagnosed Adolescent and Young Adult Cancer Patients.  Cancer. 2012 Jun 28. doi: 10.1002/cncr.27713. [Epub ahead of print]

Kwak M, Zebrack BJ, Meeske KA, Embry L, Aguilar C, Block R, Hayes-Lattin B, Li Y, Butler M, Cole S. Prevalence and predictors of post-traumatic stress symptoms in adolescent and young adult cancer survivors: a 1-year follow-up study.   Cancer. 2013 Jan 1;119(1):201-14. doi: 10.1002/cncr.27713. Epub 2012 Jun 28.

Kwak M, Zebrack BJ, Meeske KA, Embry L, Aguilar C, Block R, Hayes-Lattin B, Li Y, Butler M, Cole S.  Trajectories of Psychological Distress in Adolescent and Young Adult Patients With Cancer: A 1-Year Longitudinal Study.  J Clin Oncol. 2013 Jun 10;31(17):2160-6. doi: 10.1200/JCO.2012.45.9222. Epub 2013 May 6.

Zebrack BJ, Corbett V, Embry L, Aguilar C, Meeske KA, Hayes-Lattin B, Block R, Zeman DT, Cole S. Psychological distress and unsatisfied need for psychosocial support in adolescent and young adult cancer patients during the first year following diagnosis.  Psychooncology. 2014 Nov;23(11):1267-75. doi: 10.1002/pon.3533. Epub 2014 Mar 24.

Zebrack, Kwak M, Salsman J, Cousino M, Meeske Ka, Aguilar C, Embry L, Block R, Hayes-Lattin B, Cole S.  The relationship between posttraumatic stress and posttraumatic growth among adolescent and young adult (AYA) cancer patients. Psycho-Oncology 2015, 24: 162–168.   Published online 11 June 2014 in Wiley Online Library (wileyonlinelibrary.com). DOI: 10.1002/pon.3585

Interests:
Survivorship in childhood cancer, Epidemiology and Community Research.

 

Psychologists

Leanne Embry, PhDLeanne Embry, PhD
Associate Professor of Pediatrics
Division of Hematology-Oncology
210-567-7477

Education:
Ph.D., Clinical Psychology, University of Southern Mississippi, 2003
M.A., Clinical Psychology, University of Southern Mississippi, 1996
B.A., Psychology, Emory University, 1992

Postgraduate Training:
2003-04
Postdoctoral Fellowship, Clinical Psychology, UT Health Science Center, San Antonio

Recent Publications:
Walsh, KS, Noll, RB, Annett, RD, Patel, SK, Patenaude, AF & Embry, L. Standard of care for neuropsychological monitoring in pediatric neuro-oncology: Lessons from the Children's Oncology Group (COG). Pediatric Blood and Cancer. 2016 Feb. doi: 10.1002/pbc.25759.

Annett RD, Hile S, Bedrick E, Kunin-Batson AS, Krull KR, Emrby L, MacLean WE, Noll RB. Neuropsychological functioning of children treated for acute lymphoblastic leukemia: Impact of whole brain radiation therapy. Psycho-Oncology. 2015 Feb;24(2). doi: 10.1002/pon.3586.

Zebrack B, Kwak M, Salsman J, Cousino M, Meeske K, Aguilar C, Embry L, Block R, Hayes-Lattin B, Cole S. The relationship between posttraumatic stress and posttraumatic growth among adolescent and young adult (AYA) cancer patients. Psycho-Oncology. 2015 Feb;24(2). doi: 10.1002/pon.3585.

Zebrack BJ, Corbett V, Embry L, Aguilar C, Meeske KA, Hayes-Lattin B, Block R, Zeman DT, Cole S. Psychological distress and unsatisfied need for psychosocial support in AYA cancer patients during the first year following diagnosis. Psycho-Oncology. 2014 Nov;23(11). doi: 10.1002/pon.3533.

Whitlow PG, Caparas M, Cullen P, Trask C, Schulte C, Embry L, Nagarajan R, Johnston DL, Sung L. Strategies to improve success of pediatric cancer co-operative group quality of life studies: A report from the Children's Oncology Group. Quality of Life Research. 2014 Nov. doi:10.1007/s11136-014-0855-9.

Kwak M, Zebrack BJ, Meeske KA, Embry L, Aguilar C, Block R, Hayes-Lattin B, Li Y, Butler M, Cole S. Trajectories of psychological distress in adolescent and young adult cancer patients: A one-year longitudinal study. Journal of Clinical Oncology. 2013 Jun 10; 31(17):2160-2166. doi: 10.1200/JCO.2012.45.9222.

Kwak M, Zebrack BJ, Meeske KA, Embry L, Aguilar C, Block R, Hayes-Lattin B, Li Y, Butler M, Cole S. Prevalence and predictors of post-traumatic stress symptoms in adolescent and young adult cancer survivors: A 1-year follow-up study. Psycho-Oncology. 2013 Aug;22(8):1798-806. doi: 10.1002/pon.3217.

Noll RB, Patel SK, Embry L, Hardy KK, Pellietier W, Annett RD, Patenaude A, Lown A, Sands SA, Barakat L. Children’s Oncology Group’s 2013 blueprint for research: Behavioral sciences. Pediatric Blood and Cancer. 2013 Jun;60(6):1048-54. doi: 10.1002/pbc.24421.

Zebrack BJ, Block R, Hayes-Lattin B, Embry L, Aguilar C, Meeske K, Li Y, Butler M, Cole S. Psychosocial service use and unmet need among recently-diagnosed adolescent and young adult cancer patients. Cancer. 2013 Jan 1;119(1):201-14. doi: 10.1002/cncr.27713.

Embry L, Annett RD, Kunin-Batson A, Patel SK, Sands S, Reaman G, Noll RB. Implementation of multi-site neurocognitive assessments within a pediatric cooperative group: Can it be done? Pediatric Blood and Cancer. 2012 Sep;59(3):536-9. doi: 10.1002/pbc.24139.

Ullrich N, and Embry L. Neurocognitive dysfunction in survivors of childhood brain tumors. Seminars in Pediatric Neurology. 2012 Mar;19(1):35-42. doi:10.1016/j.spen.2012.02.014.

Research interests:
Neurocognitive and psychological sequelae of pediatric cancer diagnoses and treatment; differential impact of a cancer diagnosis for adolescent and young adult patients

Clinical interests:
Coping with diagnosis and treatment of childhood cancer; impact of cancer on the lives of adolescents and young adults; quality of life and cognitive impairment related to sickle cell disease

 

Nurse Practitioners

 

Patricia Amerson, MSN, RN, CPNPPatricia Amerson, MSN, RN, CPNP
Clinical Instructor of Pediatrics
Division of Hematology-Oncology
210-567-7477

Education:
MSN, Pediatric Nurse Practitioner,
University of Texas Health Science, San Antonio, TX, 2001
BSN, Nursing, University of Texas Health Science, San Antonio, TX, 1998

Certification:
Pediatric Nursing Certification Board, 2001

Interests:
Hemophilia
Von Wildebrand Disease

 

Ivette Jones, MSN, RN, CPNPIvette Jones, MSN, RN, CPNP
Clinical Instructor of Pediatrics
Division of Hematology-Oncology
210-567-7477

Education:
Post-Graduate Certificate, Pediatric Nurse Practitioner – Acute Care, University of Texas at El Paso, El Paso, TX, 2015
MSN, Pediatric Nurse Practitioner – Primary Care, University of Texas at El Paso, El Paso, TX, 2010
BSN, Nursing, University of Texas at El Paso, El Paso, TX, 2001

Certification:
Pediatric Nursing Certification Board, Primary Care PNP, 2010
Pediatric Chemotherapy and Biotherapy Provider, 2003

Interests:
Leukemia/lymphoma